diff --git a/Lib/fontTools/__init__.py b/Lib/fontTools/__init__.py
index 9ebb8cf..0a9807c 100644
--- a/Lib/fontTools/__init__.py
+++ b/Lib/fontTools/__init__.py
@@ -3,6 +3,6 @@
 
 log = logging.getLogger(__name__)
 
-version = __version__ = "4.22.1.dev0"
+version = __version__ = "4.22.1"
 
 __all__ = ["version", "log", "configLogger"]
diff --git a/NEWS.rst b/NEWS.rst
index 5a2fb5a..f2851f3 100644
--- a/NEWS.rst
+++ b/NEWS.rst
@@ -1,3 +1,6 @@
+4.22.1 (released 2021-04-26)
+----------------------------
+
 - [feaLib] Skip references to named lookups if the lookup block definition
   is empty, similarly to makeotf. This also fixes an ``AttributeError`` while
   generating ``aalt`` feature (#2276, #2277).
diff --git a/setup.cfg b/setup.cfg
index e8cccdd..8dabecc 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -1,5 +1,5 @@
 [bumpversion]
-current_version = 4.22.1.dev0
+current_version = 4.22.1
 commit = True
 tag = False
 tag_name = {new_version}
diff --git a/setup.py b/setup.py
index 8b72e89..3698458 100755
--- a/setup.py
+++ b/setup.py
@@ -441,7 +441,7 @@
 
 setup_params = dict(
 	name="fonttools",
-	version="4.22.1.dev0",
+	version="4.22.1",
 	description="Tools to manipulate font files",
 	author="Just van Rossum",
 	author_email="just@letterror.com",